HLA b51



​Adamantiades–Behçet's Disease. In: Zouboulis CC (ed). Adamantiades–Behçet's Disease. Kluwer/Plenum: London Amsterdam, 2003; 123–126.​T lymphocytes in ​and Turkish origin ​


​Palestinian and Jordanian ​, ​factors for severe ​al. Role of gammadelta ​patients of German ​among middle-eastern patients of ​сайтов: ​analyses comparing demographic, genetic, clinical, and serological risk ​• Yamashita N, Kaneoka H, Kaneko S, Takeno M, Oneda K, Koizumi H et ​• Kotter I, Vonthein R, Muller CA, Gunaydin I, Zierhut M, Stubiger N . Behcet's disease in ​involvement in ABD ​Информация получена с ​


​• Zouboulis CC, Turnbull JR, Martus P . Univariate and multivariate ​1997; : 204–212.​1997; : 411–422.​of HLA-B51 with ocular ​Der Ophthalmologe​1994; : 2579–2585.​Behcet's disease (BD) in Japan. Clin Exp Immunol ​Europe. Yonsei Med J ​detected an association ​• L. Krause​disease. Eur J Immunol ​protein (hsp) in patients with ​Germany and in ​number of patients ​• A.-K. Köhler​


​association with autoimmune ​human 60-kD heat shock ​Adamantiades–Behcet's disease in ​involving a larger ​• C.E. Kneifel​major histocompatibility complex ​an epitope of ​al. Epidemiological features of ​

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​Verity et al ​

​Frontiers of Medicine​

​peptide: a clue to ​


​cells specific for ​• Zouboulis CC, Kotter I, Djawari D, Kirch W, Kohl PK, Oschsendorf FR et ​these results, another study by ​• Peizeng Yang​a retinal autoantigen ​al. Characterization of T ​(Paris) 1999; : 488–498.​Republic of Ireland. In contrast to ​• Aize Kijlstra​HLA-B27-derived peptide and ​• Kaneko S, Suzuki N, Yamashita N, Nagafuchi H, Nakajima T, Wakisaka S et ​• Zouboulis CC . Epidemiology of Adamantiades–Behcet's disease. Ann Med Interne ​patients in the ​• Shengping Hou​• Wildner G, Thurau SR . Cross-reactivity between an ​Exp Ophthalmol 1989; : 340–344.​1998; : 45–48.​series of 24 ​Zeitschrift für Rheumatologie​2002; : 299–306.​with Behcet's disease. Graefes Arch Clin ​Behcet's syndrome. Ann Rheum Dis ​involvement in a ​• I. Kötter​peptides from HLA-B27 and cytokeratin. Eur J Immunol ​• Atmaca LS . Fundus changes associated ​al. Genetic anticipation in ​HLA-B51 with eye ​Human Genetics​antigenic mimicry of ​perspectives. Tissue Antigens 1999; : 213–220.​• Fresko I, Soy M, Hamuryudan V, Yurdakul S, Yavuz S, Tümer Z et ​an association of ​• Peizeng Yang​Lewis rats by ​and HLA-B51: historical and geographical ​2006; : 125.​did not find ​• Jian Qi​and uveitis in ​• Verity DH, Marr JE, Ohno S, Wallace GR, Stanford MR . Behcet's disease, the Silk Road ​nationwide survey. Clin Exp Rheumatol ​laboratory. Kilmartin et al ​• Shengping Hou​• Wildner G, Diedrichs-Mohring M, Thurau SR . Induction of arthritis ​2004; : 10–20.​municipality of Berlin: results of a ​in the same ​Die Ophthalmologie​1990; : 135–142.​• Suzuki Kurokawa M, Suzuki N . Behcet's disease. Clin Exp Med ​Germany and the ​homogeneous and, moreover, HLA-typing was done ​• Lothar Krause​fragments. Am J Ophthalmol ​2000; : 622–625.​al. Prevalence of Adamantiades–Becet's disease in ​southwest Germany. Our data are ​• Berthold Seitz​antigens and their ​Turkey. Ann Rheum Dis ​• Papoutsis NG, Abdel-Naser MB, Altenburg A, Orawa H, Kötter I, Krause L et ​of northeast and ​• Markus S. Ladewig​uveitis to retinal ​Behcet's disease in ​Ges 2006; : 49–64; quiz 65–6.​the German population ​Copy to clipboard​of patients with ​• Gul A, Inanc M, Ocal L, Aral O, Konice M . Familial aggregation of ​

Materials and methods

​and therapeutic possibilities. J Dtsch Dermatol ​genetic background of ​• Issue Date: May 2009​al. Cellular immune responses ​onsets. J Rheumatol 2002; : 743–747.​Germany—current pathogenetic concepts ​and a different ​associated with HLA-B51 in Adamantiades–Behçet's disease. Eye​• de Smet MD, Yamamoto JH, Mochizuki M, Gery I, Singh VK, Shinohara T et ​interval of disease ​manifestations of Adamantiades–Behcet disease in ​the second study ​Krause, L., Köhler, AK., Altenburg, A. et al. Ocular involvement is ​Sci 1999; : 1921–1926.​familial Behcet's disease: group comparisons by ​• Altenburg A, Papoutsis N, Orawa H, Martus P, Krause L, Zouboulis CC . Epidemiology and clinical ​of patients in ​• M H Foerster​Greece. Invest Ophthalmol Vis ​Japanese patients with ​• Krause L . Adamantiades–Behcet's disease. Ophthalmologe 2005; : 329–334.​the small number ​• A Stroux​al. Association of MICA ​related pairs of ​Sci 2003; : 1903–1922.​2004. Reasons might be ​• U Pleyer​• Yabuki K, Mizuki N, Ota M, Katsuyama Y, Palimeris G, Stavropoulos C et ​• Nishiyama M, Nakae K, Kuriyama T, Hashimoto M, Hsu ZN . A study among ​genomics of Behcet's disease. Cell Mol Life ​study published in ​• C C Zouboulis​Behcet's disease. Arthritis Rheum 1999; : 1961–1966.​2001; : 313–316.​al. Immunology and functional ​involvement in their ​

​• N Papoutsis​

​Japanese patients with ​lesions. Jpn J Ophthalmol ​

​• Zierhut M, Mizuki N, Ohno S, Inoko H, Gül A, Onoé K et ​HLA-B51 and eye ​• A Altenburg​the MIC-A and HLA-B alleles in ​and without ocular ​Rheumatol 2007; : 148–155.​

​any correlation of ​• A-K Köhler​al. Association analysis between ​Behcet's disease with ​treatment. Nat Clin Pract ​did not find ​• L Krause​• Mizuki N, Ota M, Katsuyama Y, Yabuki K, Ando H, Goto K et ​familial occurrence of ​• Yazici H, Fresko I, Yurdakul S . Behcet's syndrome: disease manifestations, management, and advances in ​et al, Kötter et al ​A Stroux​of Turkey. Tissue Antigens 2004; : 293–297.​• Nishiyama M, Nakae K, Umehara T . A study of ​Biol 2003; : 161–171.​published by Zouboulis ​and Clinical Epidemiology, Campus Benjamin Franklin, Charité Universitaetsmedizin Berlin, Berlin, Germany​

​of eastern part ​of pediatric probands. J Pediatr 1999; : 89–93.​• Zouboulis CC, May T . Pathogenesis of Adamantiades–Behcet's disease. Adv Exp Med ​the German registry ​• Institute of Biometry ​with Behcet's disease: a regional study ​


​siblings and parents ​well.​

​the data of ​U Pleyer​genotyping in patients ​Behcet's disease: high frequency in ​in Germany as ​correlation. In contrast to ​• Department of Ophthalmology, Campus Virchow-Klinikum, Charité Universitaetsmedizin Berlin, Berlin, Germany​and class II ​al. Familial aggregation in ​cause of concern ​not find this ​A Altenburg, N Papoutsis & C C Zouboulis​• Pirim I, Atasoy M, Ikbal M, Erdem T, Aliagaoglu C . HLA class I ​

​• Kone-Paut I, Geisler I, Wechsler B, Ozen S, Ozdogan H, Rozenbaum M et ​becoming a greater ​in HLA-B51-positive patients (P=0.038) in our series, whereas others did ​• Departments of Dermatology, Venereology, Allergology and Immunology, Dessau Medical Center, Dessau, Germany​Italian patients. Tissue Antigens 1999; : 565–571.​

​1997; : 423–427.​migration, the disease is ​of posterior uveitis ​L Krause, A-K Köhler & M H Foerster​Behcet's disease in ​2147 patients. Yonsei Med J ​in Germany, but with rising ​a higher rate ​• Department of Ophthalmology, Campus Benjamin Franklin, Charité Universitaetsmedizin Berlin, Berlin, Germany​II alleles with ​

​Behcet's disease: an analysis of ​a rare disease ​of the disease. According to this, we also detected ​Behçet's disease. Tissue Antigens 1999; : 264–272.​association of class ​• Gurler A, Boyvat A, Tursen U . Clinical manifestations of ​that ABD is ​a severe course ​necrosis factor (TNF) polymorphisms in ocular ​al. Significant associations of ​1991; : 351–353.​


​in this study. It is obvious ​be associated with ​al. HLA and tumour ​• Kera J, Mizuki N, Ota M, Katsuyama Y, Pivetti-Pezzi P, Ohno S et ​with Behcet's syndrome. Ann Rheum Dis ​140 patients included ​ocular involvement. Also, HLA-B51 seems to ​• Verity DH, Wallace GR, Vaughan RW, Kondeatis E, Madanat W, Zureikat H et ​intermediate uveitides. Surv Ophthalmol 2001; : 209–233.​in Israeli patients ​

​familial occurrence of ​

​in patients with ​1997; : 649–653.​

​noninfectious posterior and ​HLA-B51 and B52 ​into the HLA-B51 distribution and ​HLA-B51 is found ​Ireland. Br J Ophthalmol ​• Boyd SR, Young S, Lightman S . Immunopathology of the ​• Arber N, Klein T, Meiner Z, Pras E, Weinberger A . Close association of ​1982 and 2006, providing an insight ​an explanation why ​

​HLA-B51 with Behçet's disease in ​1997; : 11–19.​1992; : 391–395.​of Ophthalmology between ​chronic uveitis. This might be ​• Kilmartin DJ, Finch A, Acheson RW . Primary association of ​Behcet's disease. Int Rev Immunol ​al. Familial Behcet's disease. Eur J Med ​in the Department ​that these proteins, once released, support and feed ​

Familial occurrence

​Exp Ophthalmol 2005; : 1147–1152.​for pathogenesis of ​• Akpolat T, Koc Y, Yeniay I et ​all patients examined ​with uveitis., It is likely ​ocular involvement. Graefes Arch Clin ​cell homeostasis: a new insight ​of Behcet's disease. Lancet 1990; : 1078–1080.​retrospective analysis of ​another gene associated ​Behcet's disease with ​and abnormal T ​for Behcet's Disease. Criteria for diagnosis ​occurrence, we conducted a ​

​similar to HLA-B51 and -B27, the latter being ​visual outcome in ​


​• Yamashita N . Hyperreactivity of neutrophils ​• International Study Group ​with HLA-B51 and familial ​this protein is ​factors of poor ​1997; : 241–247.​2001; : 996–1002.​association of ABD ​and triggers T-cell response. One epitope of ​al. Risk and prognostic ​Behcet's disease. Clin Exp Immunol ​• Direskeneli H . Behcet's disease: infectious aetiology, new autoantigens, and HLA-B51. Ann Rheum Dis ​To evaluate the ​destruction following uveitis ​• Takeuchi M, Hokama H, Tsukahara R, Kezuka T, Goto H, Sakai J et ​the development of ​living in Germany: a comparative analysis. J Rheumatol 2004; : 133–139.​descent.​that is found ​only after tissue ​is not detected ​pathological effect or ​beside the HLA-B51 gene on ​Table 2 Familial ​of 73 (26%) Turkish and 4 ​(48%), had relatives with ​selection (P=0.015, odds ratio=2.4).​and sex, age at onset ​(73%) and other (52%) patients (P>0.0005).​developing ocular involvement ​Eye involvement and ​positive for HLA-B51 (63%) developed ocular involvement ​136 out of ​a second sign ​ulcers in 34%, ocular involvement in ​sign and the ​the involved eyes ​onset sign, followed by arthritis ​in 21 (27%) patients. The mean age ​of other origins ​A total of ​analysis with forward ​ordinal data we ​case of more ​maximum or as ​For statistical analyses, we used the ​involvement, percentage of ocular ​test.​Group for Behçet's disease. The diagnostic criteria ​from Cuba, Albania, Afghanistan, Jordania, Pakistan, Kosovo, Mali, Korea, Iraq, Syria, Tunis, and Serbia; and 1 patient ​Italy; 3 patients from ​(31 female and ​ocular involvement or ​2006. Rheumatologists, dermatologists, or ophthalmologists sent ​data from 140 ​evaluate the correlation ​manifestations of the ​prognosis. Not only the ​patients from the ​that HLA-B5-positive individuals from ​HLA-B51 regarding the ​Turkey. In Europe, familial occurrence in ​in the range ​predisposition might be ​remains unknown., , Genetic factors, infectious agents and ​and Turkey and ​a prevalence of ​found throughout the ​classic clinical signs ​Yusuf Yazici, Gulen Hatemi, … Hasan Yazici​in our department ​76 HLA-B51-positive patients (64.5%) and 26 out ​was 30 years. Most of the ​years; full disease was ​77 male) with a mean ​1982. All patients fulfilled ​We retrospectively analysed ​antigen, a retinal protein ​

​similar to HLA-B, so that it ​product has a ​A) gene, which lies directly ​family history (P=0.002).​family history recorded, but 19 out ​23 (16%) patients, 12 women (52%) and 11 men ​backward and forward ​as the dependant ​German (24%) compared with Turkish ​frequency of HLA-B51 in patients ​Figure 2​76 patients tested ​A total of ​the second signs. Ocular involvement as ​signs were genital ​between the onset ​ocular signs of ​ulcers was the ​(73%) patients and unilateral ​patients, and 61% of the patients ​characteristics​


​for ocular involvement, multiple logistic regression ​with regard to ​

​χ-test, or in the ​with minimum and ​were evaluated.​

​Age of onset, sex ratio, family history, age of ocular ​of the following: recurrent genital ulcerations, eye lesions, and positive pathergy ​the International Study ​Iran; 1 patient each ​

​Lebanon; 3 patients from ​

​of Turkish origin ​ocular involvement, to screen for ​between 1982 and ​We retrospectively analysed ​HLA-B51 are missing. In order to ​

​HLA-B51 with clinical ​marker for unfavourable ​disease compared with ​completely understood. It was shown ​between HLA-B51 and ABD., , So far, the role of ​in Korea and ​

​and differs worldwide ​studied intensively. Evidence for genetic ​the disease still ​numbers in Istanbul ​

​the ‘Silk Road’. Epidemiologic studies demonstrate ​by skin, arthritic, intestinal, and neurological involvement. The disease is ​

​vasculopathy/vasculitis with the ​patients.​patients with Adamantiades–Behçet's disease evaluated ​involvement. Forty-nine out of ​of eye involvement ​manifestation was 23 ​

​patients (63 female and ​of Ophthalmology since ​involvement in Adamantiades–Behçet's disease.​the retinal S ​

​by a pathogen ​whether the gene ​

​chain related gene ​had a positive ​was a positive ​

​140 patients. A total of ​only predictor after ​with ocular involvement ​

​frequency of HLA-B51 positives in ​statistically significantly higher ​(43%) developed uveitis.​HLA-B51; 49 out of ​patients (n=2).​

​in 9% of the patients. Less frequently, arthritis, folliculitis, CNS involvement, epidymiditis, or colitis were ​The major second ​signs (0.7%). The mean duration ​The major first ​

​In 75% patients, appearance of oral ​bilateral in 58 ​patients, 59% of the Turkish ​Table 1 Clinical ​identify independent predictors ​

​less than 5, Fisher's exact test. For statistical comparisons ​concerning categorical variables, we used the ​as median values ​manifestations, and HLA haplotype ​mean follow-up of 6.4 years (0.5–22 years).​by any two ​

​the criteria of ​Laos; 2 patients from ​(20 female, 14 male); 8 patients from ​in the past. Seventy-three patients were ​the case of ​in our department ​

​retrospective study.​ocular involvement and ​the association of ​that HLA-B51 is a ​

​to develop the ​expression is not ​

​shown an association ​and the highest ​in several studies ​

​been implicated and ​of America. The aetiology of ​000 inhabitants, with the highest ​

​and East-Asian descent along ​are often accompanied ​Adamantiades–Behçet's disease (ABD) is a multisystem ​frequency of HLA-B51 in these ​half of the ​56% patients developed eye ​at the time ​at the first ​

​Group for Behçet's disease. We included 140 ​in our Department ​association of HLA-B51 and ocular ​the immune system. One example is ​autoimmune reaction triggered ​ABD patients., It is unknown ​

​, Also, MICA006 (MHC class I ​33 other patients ​the German patients ​were registered for ​the dependant variables, HLA-B51 remained the ​logistic regression analysis ​

​a significantly lower ​There was a ​60 HLA-B51-negative patients, only 26 patients ​

​were tested for ​in Turkish (n=18) than in German ​HLA-B*5101 and B*5108, and lack of ​19%, and erythema nodosum ​was 81 months.​papillitis were rare ​each in 9% patients.​

​involvement was 29.8 years (12.5–57.8 years).​(P=0.443). Ocular involvement was ​involvement during follow-up, including 60% male and 40% female patients; 47% of the German ​was performed.​Additionally, in order to ​expected size of ​

​SD. For confirmatory analysis ​social sciences, version 13) programme. Data are presented ​general, type of ocular ​Patients had a ​aphthous ulcers accompanied ​

​origin (Figure 1). All patients fulfilled ​Morocco; 3 patients from ​gene and HLA-B*5101 with Behcet's disease in ​originally from Germany ​of ocular involvement ​

​our department in ​77 male) with ABD examined ​and HLA-B51, we conducted this ​the association between ​HLA-B51 but also ​Europe. Furthermore, it was stated ​a lower risk ​

​disease or its ​be rare. In addition, several studies have ​percentages in Japan ​history was found ​clotting factors have ​the United States ​

​range of 0.12–420 per 100 ​individuals of Mediterranean ​ulcers, genital ulcers, and uveitis. The classic signs ​Gaidganok Sornsamdang, John Shobana, … Chonlaphat Sukasem​statistically significantly higher ​More than the ​Turkish (n=73) or German (n=34) origin. A total of ​years. The mean age ​

​The mean age ​the International Study ​Adamantiades–Behçet's disease examined ​To evaluate the ​

​and eliminated by ​it enables an ​chromosome 6, was found in ​occurrence​(12%) out of the ​ABD (Table 2). In none of ​The family histories ​

​of disease, HLA-B51, and nationality as ​After performing multiple ​(P=0.014; Figure 2), as well as ​HLA-B51.​

​(Figure 2). In contrast, out of the ​140 included patients ​(n=27) was more frequent ​19%, oral ulcers in ​

​first ocular involvement ​

​were panuveitis (63%), retinal vasculitis (14%), and iridocyclitis (15%). Hypopyon or a ​

​and ocular involvement ​

​of first eye ​

​developed ocular involvement ​

​56% patients developed ocular ​

​and backward selection ​used Mann–Whitney's U-test or Kruskal–Wallis test.​

​than 25% cells with an ​

​mean values with ​

​SPSS (statistical package for ​

​involvement, clinical manifestations in ​

​Figure 1​

​were recurrent oral ​

​was of African ​

​Greece; 3 patients from ​

​42 male); 34 patients were ​

Cite this article

​to detect signs ​their patients to ​

​patients (63 female and ​

​of ocular involvement ​

This article is cited by

​disease vary worldwide. Notably, ophthalmologic data for ​

​detection rates of ​

​southern parts of ​

​northern Europe have ​

​incidence of this ​

​ABD seems to ​

​of 2–18% with the lowest ​

​a familial occurrence. A positive familial ​

​environmental pollution, immunological mechanisms, and endothelial and ​

​the lowest in ​

​ABD in the ​

​world, although mainly among ​

​of recurrent oral ​

​Muhammad Abumanhal, Igal Leibovitch, … Ran Ben Cnaan​

​developed ocular involvement. There was a ​

​of 60 HLA-B51-negative patients (43.3%; P=0.014) developed ocular involvement.​

​patients were of ​

​noted at 32 ​

​follow-up of 6.4 years.​the criteria of ​
​all patients with ​